Journal article
Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle
HT Tran, S Liong, R Lim, G Barker, M Lappas
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Gestational diabetes mellitus (GDM), which complicates up to 20% of all pregnancies, is associated with low-grade maternal inflammation and peripheral insulin resistance. Sterile inflammation and infection are key mediators of this inflammation and peripheral insulin resistance. Resveratrol, a stilbene-type phytophenol, has been implicated to exert beneficial properties including potent anti-inflammatory and antidiabetic effects in non-pregnant humans and experimental animal models of GDM. However, studies showing the effects of resveratrol on inflammation and insulin resistance associated with GDM in human tissues have been limited. In this study, human placenta, adipose (omental and subcut..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025). Dr. Stella Liong is a recipient of the Glyn White Research Fellowship by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Research Foundation, the Early Career Researcher Fellowship by The University of Melbourne, and the Postdoctoral Award by the Endocrine Society of Australia (ESA). Funding for this study was provided by grants from the Norman Beischer Medical Research Foundation, Diabetes Australia, Rebecca L Cooper Medical Research Foundation and Austin Medical Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.